Phezam blisters 400mg/25mg #60 - Neurology

Phezam blisters 400mg/25mg #60 - Neurology

Brand: Bulgaria
Product Code: 074
Availability: In Stock
Price: $28.00


blisters, #60
Piracetam 400 mg
Cinnarizine 25 mg
Other ingredients: lactose, colloidal silicon dioxide, magnesium stearate, gelatin.
Pharmacological properties: a combination of piracetam and cinnarizine improves both blood flow and metabolism neurocytes brain, auditory and visual analyzers, contributing to the process of renewal of their functions. Both components are mutually potentiate the action aimed at reducing vascular resistance, increased durability neurocytes in ischemia. The main mechanism of action is associated with improved metabolic, bioenergetic processes in the nerve cell, increasing the rate of turnover of informational macromolecules and the activation of protein synthesis. Thanks piracetam increases ATP synthesis, improves utilization of oxygen in the brain, the processes of glycolysis and protein synthesis, increased exchange fosfatilholina, fosfadiletanolamina; improves GABA-ergic, cholinergic and glutamatergic neurotransmission, increased flexibility of the cell membrane with aging, inhibited lipid peroxidation, improves blood rheology . Cinnarizine, blocking the transmembrane transport of Ca2 + into the cell, reduces vascular tone, sensitivity to the vasoconstrictor action of adrenaline, noradrenaline, bradykinin, improves the rheological properties of blood, increases the volume of the regional blood flow without the occurrence of steal syndrome, increases the resistance of cells to hypoxia, no effect on blood pressure and heart rate, potentiates the anti-ischemic effect of piracetam. Preventing excessive Ca2 + overload neurocytes fast interrupt response glutamate-calcium cascade that underlie damage neurocytes.
Combination drug is rapidly and completely absorbed in the gastrointestinal tract. Cinnarizine reaches maximum concentration in plasma at 1 h after oral administration. Completely metabolized, bound by 91% to plasma proteins. 60% is excreted unchanged in the feces, residues - in the urine as metabolites. Maximum plasma concentration is achieved in piracetam 2-6 hours easily penetrate the blood-brain barrier.
INDICATIONS: application fezam shown at:
• cerebrovascular disorders: cerebral atherosclerosis, which is accompanied by an ischemic stroke, in recovery after a hemorrhagic stroke, traumatic brain injury;
• violation of the memory function of thinking, concentration;
• vascular dementia;
• mood disorder (with depression and irritability);
• encephalopathy of different origins;
• labirintopatii various origins (dizziness, tinnitus, nystagmus, nausea, vomiting), Meniere's syndrome;
• in treatment of sensorineural hearing loss;
• in treatment of disorders of visual function in open-angle glaucoma with stable intraocular pressure, macular degeneration, high myopia complicated;
• in treatment of hypertension;
• in treatment of neuro dystonia;
• prevention kinetoses;
• prevention migraine
• to improve learning and memory in children with a delay of intellectual development.
Application: Depending on the severity of the disease adults appoint 1-2 capsules 3 times a day for children - 1-2 capsules 1-2 times a day for 1-3 months.
CONTRAINDICATIONS: Hypersensitivity to the drug, severe renal failure, I trimester of pregnancy and breast-feeding, the age of 5 years.
SIDE EFFECTS: very rarely - hypersensitivity reactions (rash, photosensitivity).
Cautions: caution is prescribed for liver and kidneys. In severe renal insufficiency is not prescribed in high doses, even if the patient is on chronic hemodialysis.
The drug may give false positive results in a doping control of athletes, as well as the determination of radioactive iodine (iodine-containing dyes because of the capsule shell). In treatment fezam should avoid alcohol. Use caution in patients with Parkinson's disease.
Despite the lack of evidence of teratogenicity of the drug is not recommended to use it in the I trimester of pregnancy and during lactation.
INTERACTION: while admission may potentiate sedative CNS depressants, tricyclic antidepressants and alcohol, as well as neuroprotective and antihypertensives. Vasodilators increase the effect of the drug, and increase in blood pressure - impaired.
OVERDOSE: irritability (in children).
Storage: Store in a dry, dark place at a temperature of 25 ° C.

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