Description and manual
ATTENTION! TAD-600 is not in the doping list and does not contain anything that could be related for prohibited substances from the doping list
The pharmacological properties of TAD 600
Drug tad 600 (tad) for many years, is one of the most popular all over the world. Most athletes know what to buy tad-600 it means to take another step on the way to achieving new heights. The basis of the drug is glutathione is a natural triple, which consists of several amino acids: glycine, cysteine and glutamic acid.
Glutathione is found in all cells of the human body, is involved in many important processes of life and perform various functions. To meet the body's need for glutathione, a great solution is to buy tad 600. Glutathione due to its antioxidant function, protects cells from free radicals and their negative effects.
The presence of glutathione in sufficient quantities allows the athlete to recover faster after exercise. Many specialists to preserve the integrity of cellular structures is recommended to buy tad 600. Another important function of the drug is detoxification of toxic substances of internal and external origin. Detoxification takes place mostly in the liver cells.
A useful feature of glutathione is its active participation in strengthening the immune system. This feature makes the drug tad 600 is a particularly important aspect for the human body. The integrated positive effect on the body increases the value of the use of funds. Thus, the correct choice - to buy tad 600 for prevention of various diseases and increase the protective forces of the body.
It must be remembered that the content of glutathione in the body may be reduced due to various factors. For example, when the wrong diet, use of alcohol and drugs, taking certain medications, Smoking.
In addition, the scientists found that production of glutathione after 40 years it begins to decrease, and every three months by about 5%. In this situation the ideal solution would be to buy tad-600 and to ensure the flow of substances in the right amount.
Indications for use
The drug is used for effective recovery of glutathione in the body, for the treatment and prevention of lesions caused by radioactive radiation. The drug can be applied separately and in combination ("cocktail Milan"). In the "Milan cocktail" tad 600 plays an important role and enhances the action of the drug esafosfina. To buy tad 600 will be useful for applications in hepatopathy.
Recommendations for use
Secondary forms: intravenously or intramuscularly daily slowly administered 1-2 ampoules TAD 300 or added as infusion solution at the prescription of the attending physician.
More complex forms: intravenously or intramuscularly daily slowly administered 1-2 ampoules TAD 600 or added as infusion solution at the prescription of the attending physician.
May cause skin rash, which after discontinuation of the drug disappears.
Composition: Reduced glutathione (GSH).
Form release: in the package five vials, each containing 0,646 g sodium, detoxifying means reduced glutathione lyophilized.
Storage conditions: it is impossible to prevent the temperature rise above 30 °C (86° F). Keep out of reach of children. Shelf life – 36 months.
Instructions for medical use of the drug TAD-600
Powder lyophilized for solution preparation for
intravenous administration of 600 mg together with the solvent– water for
injection 4 ml
One vial with powder contains
active substance - glutathione restored the sodium salt 0,646 g,
Crystalline, hygroscopic powder white docelowego color.
The reconstituted solution is clear, colorless elizveta-yellow liquid.
ATC code V03AB32
After intravenous infusion of 2 g/m2 of glutathione, plasma total glutathione concentrations increased from 17.5 ± 13.4 mmol/l to 823 ± 326 mmol/L. the Volume of distribution of exogenous glutathione 176 ± 107 ml/kg. the half-life of 14.1 ± 9.2 minutes. The concentration of cysteine in plasmatrone increased from 8.9 ± 3.5 m mol/l to 114 ± 45 m/mol after infusion. Despite increases in cysteine, total concentration in plasma total cysteine, cystine and the mixed disulfide is decreased, which indicates an increase of the transport properties of cysteine inside the cell.
Urinary excretion of glutathione and cysteine were increased by 300% and 10%, respectively, 90 minutes after injection.
Glutathione is a physiologic Tripeptide of glutamic acid, cysteine and glycine,which is involved in several biological processes and has an important role in detoxification, protecting cells from the harmful effects of xenobiotics, free radicals and radiation. Preclinical and clinical studies have shown a protective role of glutathione in a number of situations that cause pathological cell damage (poisoning with such substances as ethyl alcohol,paracetamol, salicylates, phenobarbital, tricyclic antidepressants,organophosphorous insecticides, etc.).
It is also observed that glutathione affects the activity of many chemotherapeutic drugs, reducing tissue levels of endogenous glutathione and reduces oxidative stress caused by tumor process.
The use of such drugs as cisplatin and its derivatives for the prevention of neurotoxicity induced by chemotherapeutic drugs, was due to the fact that platinum is accumulated in the peripheral nervous system, especially the ganglia back nerve roots. Therefore, using substances such as glutathione, can prevent the initial accumulation of platinum in nerve root ganglia of the rear.
Clinical studies confirmed that the infusion of glutathione, before the introduction of antineoplastic agents in patients with carcinomas of the ovary, carcinoma of stomach and colorectal cancer provides effective protection from renal failure and neurotoxicity caused by cisplatin and oxaliplatin, which allows,if necessary, to achieve higher cumulative doses of anticancer agents.
Indications for use
- prevention of neurotoxicity associated with chemotherapy cisplatin or other related compounds
Method of application and doses
Daily dose of TAD 600обычно recommended for patients receiving chemotherapy with cisplatin and related compounds is 1.5 g/m2 (corresponding to 2.5 g) by slow intravenous infusion.
The dose, however, depends on age, weight and clinical condition of the patient, and the dose grafica the introduction of chemotherapeutic agents.
In case of concurrent administration of glutathione and chemotherapeutic agents,intravenous infusion of TAD 600 has to be done 15-30 minutes prior to chemotherapy.
In the case of long-term treatment, may reduce dose (600 mg or 300mg), which may be administered intramuscularly or slowly intravenously.
- febrile reactions
- venous thrombosis or phlebitis and hemorrhage at the injection site
- skin rash, which disappeared after discontinuation of treatment
- mild pain at the injection site
- hypersensitivity to the active substance
No reports of pharmacological interactions with glutathione, have been reported in the literature.
In recommended doses, TAD 600 does not interfere with the therapeutic activity of chemotherapeutic agents.
In the event of adverse reactions when administered intravenously,the use of the drug should be discontinued immediately.
Warning: the preparation is intended for parenteral use, you should make a visual inspection , in order to determine the presence of particles or variations in the color of the drug. Do not use in case of presence of turbidity or precipitation.
Data on safety and effectiveness of lekarstvennogo in children and adolescents under 18 years no
Pregnancy and lactation
The available data show that glutathione,being a physiological substance, present in cells, does not cause unwanted effects in women during pregnancy or breast-feeding.
Preclinical studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/fetal development,parturition and postnatal development.
Symptoms – not a single case of overdose.
Treatment if necessary can be used symptomatic treatment.
Form of release and packing
At 0.646 g of the drug is placed in a transparent glass bottle,sealed with a rubber stopper and sealed with aluminium cap.
For 4 ml of solvent is poured into transparent glass vials, sealed with rubber stopper and sealed with aluminum caps.
The bottles self-adhesive label pasted.
10 vials with the drug together with 10 vials of diluent and instructions for medical use is placed in cardboard pack.
Keep at temperature not above 25 °C .
Keep out of reach of children!
5 years. The drug is not used after the term has been expired.
Biomediсa Foscama,Chemical-pharmaceutical company S. p. A., Italy